小儿抗感颗粒的药效学实验研究

目的观察小儿抗感颗粒的解热、镇痛、抗炎作用。方法采用皮下注射干酵母造成大鼠发热模型,观察其解热作用;采用醋酸扭体法观察其镇痛作用;采用二甲苯致小鼠耳廓肿胀观察其抗炎作用。结果小儿抗感颗粒能明显降低大鼠发热模型的体温,提高小鼠痛阈值,抑制二甲苯致小鼠耳廓肿胀。结论小儿抗感颗粒具有显著的解热、镇痛、抗炎作用。

Research on pharmacodynamics of xiaoerkanggan granular

Objective To investigate the antipyretic, analgesic and antiinflammatory effects of xiaoerkanggan granular. Methods Dry yeast was administrated to rats by subcutaneous injection to induce pyretogenesis. The analgetic effect was demonstrated using pain models induced by acetic acid. The antiinflammatory effect was demonstrated using auricle edema induced by xylene in mice. Results The drug possessed the actions of eliminating-heat, relieving pain, and anti-inflammation. Conclusion The results suggest that xiaoerkanggan granular have analgesic, antipyretic and antiin- flammatory effects.