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| P66shc基因多态性及单体型与和田维吾尔族长寿人群肾功能衰退的关系研究 | |
| 引用本文： | 李素华,徐新娟,梁晓慧,张俊仕,孙理华.P66shc基因多态性及单体型与和田维吾尔族长寿人群肾功能衰退的关系研究[J].新疆医科大学学报,2011,34(10):1060-1064,1069. |
| 作者姓名： | 李素华 徐新娟 梁晓慧 张俊仕 孙理华 |
| 作者单位： | 1. 新疆医科大学第一附属医院肾病科,乌鲁木齐,830000 2. 新疆医科大学第一附属医院心脏中心高血压科,乌鲁木齐,830000 3. 新疆医科大学第五附属医院心内科,乌鲁木齐,830000 |
| 基金项目： | 国家自然科学基金项目，新疆维吾尔自治区心血管病研究重点实验室开放课题项目 |
| 摘 要： | 目的探讨P66shc基因rs8191981、rs4845401位点多态性与和田维吾尔族长寿人群肾功能衰退的关系。方法采用多重SNaPshot方法对在65例肾功能减退(病例组)和47例肾功能正常者(对照组)的P66shc基因rs8191981、rs4845401位点多态进行基因分型。结果病例组和对照组P66shc基因rs8191981、rs4845401位点的基因型频率、等位基因频率及单体型分布差异均无统计学意义(P>0.05);与长寿老人肾功能减退的关联分析显示:P66shc基因所测位点多态性与维吾尔族长寿老人肾功能减退不相关(P>0.05)。结论 P66shc基因rs8191981、rs4845401位点多态可能与新疆维吾尔族长寿人群肾功能减退无关。 |
| 关 键 词： | P66shc基因 肾功能减退 多态性 |
Research on relationship between longevity in Hetian Uygur population and polymorphisms and haplotypes of the P66shc gene |
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| LI Su-hua,XU Xin-juan,LIANG Xiao-hui,ZHANG Jun-shi,SUN Li-hua.Research on relationship between longevity in Hetian Uygur population and polymorphisms and haplotypes of the P66shc gene[J].Journal of Xinjiang Medical University,2011,34(10):1060-1064,1069. | |
| Authors: | LI Su-hua XU Xin-juan LIANG Xiao-hui ZHANG Jun-shi SUN Li-hua |
| Institution: | LI Su-hua1,XU Xin-juan2,LIANG Xiao-hui2,ZHANG Jun-shi2,SUN Li-hua3(1Department of Nephropathy,2Department of Hypertension,The First A f filiated Hospital,3Department of Cardiology,The Fifth A f filiated Hospital,Xinjiang Medical University,Urumqi 830000,China) |
| Abstract: | Objective To study the P66shc gene polymorphism in rs8191981,rs4845401 polymorphism of Hetian Uygur longevity group with renal function decline in the relationship.Methods With the method of Multiplex SNaPshot reaction,rs8191981,rs4845401 polymorphism genotypin in 65 cases of renal dysfunction(case group) and 47 cases with normal renal function(control group) were analyzed.Results P66shc gene rs8191981 and rs4845401 genotype frequency,allele frequency and haplotype distribution in normal and impaired renal ... |
| Keywords: | P66shc gene renal dysfunction polymorphism |
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