Effects of heparin on transforming growth factor-β1 and extracellular matrix components in the glomeruli of diabetic rats |
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| Authors: | Yuanhong Li Lixun Peng Muxun Zhang Jinzhi Ouyang Jianhua Zhang |
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| Institution: | (1) Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030 Wuhan |
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| Abstract: | Summary The effects of heparin on the expression of transforming growth factor-β1 (TGF-β1) and two extracellular matrix components laminin (LN) and fibronectin (FN) in diabetic rat glomeruli were investigated. Twenty-six
rats were randomly divided into control group (C,n=8), diabetic group (D,n=9), and diabetes+heparin group (DH,n=9). After 8-week therapy of heparin (200 U once daily by abdominal injection), TGF-β1, LN and FN expression in glomeruli was detected by immunohistochemical method. The results showed that the expression levels
of TGF-β1, LN and FN were higher in group D than in group C. It was found that heparin could reduce 24-h urinary albumin excretion
and inhibit overexpression of TGF-β1, LN and FN in glomeruli of diabetic rats. It suggested that the inhibitory effect of heparin on diabetic glomerular sclerosis
was at least partly related with the inhibition of TGF-β1 expression.
LI Yuanhong, female, born in 1973, Resident |
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| Keywords: | diabetic nephropathy heparin transforming growth factor-β 1 extracellular matrix |
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