1759例甲状腺疾病患者TRAb，TGAb，TMAb联检结果分析

目的 通过对1759例甲状腺疾病患者TRAb,TGAb,TMAb联合检测结果的分析,探讨3种甲状腺自身抗体在甲状腺疾病鉴别诊断中的应用价值.方法 收集2002-2006年在山东省甲状腺疾病防治中心就诊的甲状腺疾病患者1759例,根据病史、症状、体征、化验及辅助检查结果分为6组.观察各组TRAb,TGAb,TMAb测定值的分布情况,各组间率的比较采用卡方检验.结果 (1)TRAb强阳性仅存在于甲亢患者(A、B两组),其他4组阳性率均很低,且测定值均小于50 u/L;(2)6组中TGAb,TMAb各档几乎均有分布,阳性率从高到低依次为D组(高达91.53%,94.92%)、C组、A组与B组、E组、F组;(3)A组与C组TGAb,TMAb强阳性率及TGAb阳性率差异均无统计学意义,仅TMAb阳性率c组略高于A组.结论 TRAb可作为甲状腺疾病的鉴别诊断依据;TGAb,TMAb强阳性对AITD及其他甲状腺疾病的鉴别有一定临床价值;不同类型甲状腺疾病患者的TGAb,TMAb存在异质性.

Analysis of Combining Measure Value of TRAb,TGAb and TMAb of 1759 Patients with Thyroid Disease

Objective To determine serum TRAb,TGAb and TMAb of patients with thyroid disease,and to explore the application of three thyroid antibodies in differentiating thyroid disease.Methods There were 1 759 patients with thyroid disease collected from 2002-2006,and divided into six groups by their clinical data to investigate the distribution of three antibodies in six groups and compare the different positive ratio by chi-square test.Results 1.TRAb was strong positive only in group A and B,and lower positive(under 50 u/L) in the other groups.2.The different increased levels of TGAb and TMAb existed in all six groups,and the positive rates from the highest to the lowest were group D(91.53%,94.92%),group C,group A and B,group E,group F.3.The strong positive rates of the TGAb and TMAb and the difference of positive rates of the TGAb in groups A and C were not statistically significant.Conclusions TRAb could be the key to diagnosis and differentiatation of thyroid disease;TGAb and TMAb which are strong positive help to differentiate AITD and other thyroid diseases clinically to some extent.There is heterogeneity of TGAb and TMAb among patients with different thyroid diseases.