肝肾综合征的治疗进展

肝肾综合征是继发于严重肝功能障碍和门静脉高压基础之上的功能性肾衰竭，病死率极高。其发病机制复杂，目前仍没有确切有效的治疗方法，除对基础肝病的积极治疗外，肝移植是治疗肝肾综合征最好的方法。血管扩张药物因为副作用和缺乏临床研究证据，不再推荐使用。特利加压素疗效较肯定，但撤药易复发。分子吸附再循环系统治疗、经颈静脉肝内门体分流术在改善肾功能方面仍有待进一步研究。本文对近期肝肾综合征的治疗进展作一综述。

Advance Research on Hepatorenal Syndrome Therapy

Hepatorenal syndrome（HRS） is a functional renal failure that occurs in patients with severe liver disease and portal hypertension and associated with high mortality. The pathogenesis of HRS is complex. Until recently, there was still no effective therapy for HRS. Besides of general management measures for liver disease, liver transplantation is the definitive treatment for HRS. Renai vasodilators are no longer recommended due to their adverse effects and the lack of clinical evidence,Terlipressin is an effective treatment, however some patients have a recurrence after the drug is withdrawn. Further research is necessary to use of molecular adsorbent recycling system and transjugular intrahepatic portosystemic shunt in the treatment of HRS. There are advances of therapeutic methods for the patient with HRS in this text.