Role of free nitrogen and oxygen radicals in the pathogenesis of lipopolysaccharide-induced endotoxemia |
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| Authors: | T V Sanikidze N G Tkhilava M B Papava I V Datunashvili M T Gongadze D D Gamrekelashvili V I Bakhutashvili |
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| Institution: | (1) Tbilisi State Medical University, Georgia;(2) Institute of Experimental and Clinical Medicine, Georgian Academy of Sciences, Georgia;(3) Institute of Experimental and Clinical Biotechnology, Georgian Academy of Sciences, Georgia |
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| Abstract: | We studied molecular mechanisms of changes in oxidative metabolism under conditions of experimental lipopolysaccharide-induced
endotoxemia. Generation of reactive nitrogen and oxygen species in mice increased 18 h after treatment with lipopolysaccharide.
These changes contributed to inactivation of enzymes and enzyme complexes (ribonucleotide reductase, NADH-ubiquinone oxidoreductase,
and cytochrome c oxidase), dysfunction of the mitochondrial electron transport chain, and development of oxidative stress. Plaferon LB protected
mice from the toxic effect of lipopolysaccharide.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 141, No. 2, pp. 172–176, February, 2006 |
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| Keywords: | nitric oxide superoxide radical oxidative stress lipopolysaccharide Plaferon LB |
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