Deletion of a coordinate regulator of type 2 cytokine expression in mice |
| |
Authors: | Mohrs M Blankespoor C M Wang Z E Loots G G Afzal V Hadeiba H Shinkai K Rubin E M Locksley R M |
| |
Affiliation: | Howard Hughes Medical Institute, University of California San Francisco, San Francisco, CA 94143, USA. |
| |
Abstract: | Mechanisms that underlie the patterning of cytokine expression in T helper (T(H)) cell subsets remain incompletely defined. An evolutionarily conserved approximately 400-bp noncoding sequence in the intergenic region between the genes Il4 and Il13, designated conserved noncoding sequence 1 (CNS-1), was deleted in mice. The capacity to develop T(H)2 cells was compromised in vitro and in vivo in the absence of CNS-1. Despite the profound effect in T cells, mast cells from CNS-1(-/-) mice maintained their capacity to produce interleukin 4. A T cell-specific element critical for the optimal expression of type 2 cytokines may represent the evolution of a regulatory sequence exploited by adaptive immunity. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|