| 口服苯妥因锌在兔体内的药代动力学研究 |
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| 引用本文： | 蒲其松,李毓倩,卢丹,陈湛芳,李毓忠,邵小江,张艺,霍生青. 口服苯妥因锌在兔体内的药代动力学研究[J]. 农垦医学, 1991, 0(4) |
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| 作者姓名： | 蒲其松 李毓倩 卢丹 陈湛芳 李毓忠 邵小江 张艺 霍生青 |
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| 作者单位： | 石河子医学院药学系，石河子医学院药学系，石河子医学院药学系，石河子医学院药学系，石河子医学院药学专业，石河子医学院药学专业，石河子医学院药学专业，石河子医学院药学专业 实习生，实习生，实习生，实习生 |
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| 摘 要： | 兔口服苯妥因锌或苯妥因钠后,用紫外分光光度法测定了血清中苯妥因的浓度用原子吸收分光光度法测定了血清中锌或铜的含量。结果表明,苯妥因的两种无机盐制剂,AUC,Cmax,Tmax 等主要药代动力学参数差异无显著性。苯妥因锌组血清中锌浓度变化不大,苯妥因钠组血清中锌浓度随血清中苯妥因浓度而变化。两药均使血清中铜含量未改变。
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| 关 键 词： | 苯妥因锌 苯妥因钠 药代动力学 |
PHARMACOKINETIC STUDY ON PHENYTOIN ZINC(ORAL)IN RABBITS |
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| Pu Qisong Li Yuqian Lu Dan. PHARMACOKINETIC STUDY ON PHENYTOIN ZINC(ORAL)IN RABBITS[J]. Agricultural Reclamation Medicine, 1991, 0(4) |
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| Authors: | Pu Qisong Li Yuqian Lu Dan |
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| Affiliation: | Pu Qisong Li Yuqian Lu Dan Department of Pharmacy,Shihezi Medical College Li Yuzhong Shao Xiaojiang Zhang Yi Huo Shengqing Tvainees,Pharmacy Major,Shihezi Medical College |
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| Abstract: | The serum concentraton of Phenytoin was determined with ultraviolet Spectrophotometry and the content of Zn and Cu in the serum was determined with atomic absoption spectrophotometry respe- ctively after phenytoin zinc and phenytoin sodium were given orally to the rabbits.Theresult revealed no marked differences in principal pharm- acokinetics parameters (AUC,C max,T max )of both inorganic salts,Zine concentration of the phenytoin zinc group(serum)had no remarkable, changes while the zinc concentration of the phenytoin sodium group(serum) changed along with the change of the concentration of phenytoin.The Ca content remained unchanged with both drugs. |
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| Keywords: | phenytoin zinc phenytoin sodium pharmacokinetics |
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