先天性畸形儿母婴弓形虫感染的血清学研究

本文对先天性畸形儿母婴弓形虫感染进行了血清学研究.82例先天性畸形儿弓形虫抗体阳性率为32.89%,抗原阳性率为60.61%.79例畸胎儿产妇弓形虫抗体阳性率为25.21%,抗原阳性率为40.63%.两者弓形虫抗体阳性率均显著高于正常人群.77例病理组织诊断阳性的畸胎儿弓形虫抗体阳性率为41.56%,抗原阳性率为60.38%;其产妇弓形虫抗体阳性率为25. 81%,抗原阳性率为41.37%.弓形虫抗体阳性的畸形儿,其母血清抗体阳性率高达62.50%,而弓形虫抗体阴性的畸形儿其母亲血清阳性率只有18.20%,两组间差异非常显著.提示:弓形虫感染可能是造成先天性畸形的重要病因之一;母婴垂直传播是弓形虫先天性感染的途径.

SEROLOGICAL STUDY ON TOXOPLASMA INFECTION IN POSTPARTUM WOMEN AND FETUS WITH CONGENITAL DEFORMITY

Serological study on Toxoplasma infection in postpartum women and fetus with congenital deformity was carried out. In 82 fetus with congenital deformity,the positive rate for antibody detection was 32.89%,and 60. 61% for antigen detection. In 79 postpartum women who gave birth to congenitally deformed fetus, the Toxoplasma antibody positive rate was 25.21% and the antigen positive rate was 40. 63%. The positive rate for antibody detectionof both groups was obviously higher than that of the normal control group. Among 77 patho-logicaly diagnosised deformed fetus,the positive rate for antibody was 41.56%, and positive rate for antigen was 60. 38%, while their mother's antibody and antigen positive rate was 25.81% and 41. 37% respectivally. The positive rate of antibody detection in mothers of deformed fetus with positive antibody detection was 62. 50%, where as with deformed fetus of negative antibody detection,their maternal antibody positive rate was 18.20% only. The difference between the two groups was marked. It suggested that the Toxoplasma infection might be an important cause of congenital malformation, the route of infection is vertical transmission from mother to fetus.