Induction of hepatic cytochrome P-450c-dependent monooxygenase activities by dantrolene in rat |
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| Authors: | Z Jayyosi M Totis H Souhaili C Goulon-Ginet M H Livertoux A M Batt G Siest |
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| Institution: | 1. Centre du Médicament, U.A. C.N.R.S. 597, 30 rue Lionnois, 54000 NancyFrance;2. Laboratoire de Chimie Théorique, Faculté des Sciences, 54100 Vandoeuvre-les-Nancy, France;1. Department of Materials Science and Nanoengineering, Rice University, 6100 Main St, Houston, TX 77005, USA;2. Departamento de Química, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627–Pampulha, CEP 31270-901, Belo Horizonte, MG, Brazil;3. Instituto Federal de Minas Gerais, Campus Congonhas, Av. Michael Pereira de Souza, 3007 - Campinho, CEP 36415-000, Congonhas, MG, Brazil;4. Universidade Federal do Rio Grande do Norte, Campus Universitário Lagoa Nova, CEP 59072-970, Natal, RN, Brazil;5. Departamento de Física Aplicada, Universidade Estadual de Campinas, Rua Sérgio Buarque de Holanda, 777, CEP 13083-859, Campinas, SP, Brazil;6. Centro de Pesquisas Avançadas em Grafeno, Nanomateriais e Nanotecnologias, Universidade Presbiteriana Mackenzie, Rua da Consolação, 930, CEP 01302-907, São Paulo, SP, Brazil;7. Departamento de Química, Universidade do Minho, Campus de Gualtar, 4710-057, Braga, Portugal;8. SABIC Americas Inc, Sugar Land, TX 77478, USA;1. Key Laboratory of Wood Materials Science and Utilization (Beijing Forestry University), Ministry of Education, 35 Qinghua East Road Haidian District, Beijing, 100083, China;2. Beijing Key Laboratory of Wood Science and Engineering, Beijing Forestry University, 35 Qinghua East Road Haidian District, Beijing, 100083, China;3. College of Materials Science and Technology, Beijing Forestry University, 35 Qinghua East Road Haidian District, Beijing, 100083, China;4. Department of Mechanical and Energy Engineering, University of North Texas, Denton, TX, 76203, USA;5. Department of Biochemistry & Molecular Biology, Michigan State University, 603 Wilson Road, East Lansing, MI, 48824, USA;6. Great Lakes Bioenergy Research Center-Michigan State University, 1129 Farm Lane, East Lansing, MI, 48824, USA;1. School of Pharmaceutical Sciences, Yanbian University Yanji, PR China;2. Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, Yanbian University, Yanji, 133000, PR China;3. Department of Pharmacy, Yanbian University Hospital, Yanji, PR China;1. Department of Psychology, Faculty of Humanities and Social Sciences, ?zmir Bak?rçay University, ?zmir, Turkey;2. Department of Physiology, Faculty of Medicine, Ege University, Bornova, ?zmir, Turkey;1. Department of Metallurgical and Materials Engineering, Universidade Federal do Rio de Janeiro – COPPE/UFRJ, Rio de Janeiro, RJ, Brazil;2. Ternium Brasil, Rio de Janeiro, RJ, Brazil;1. Institute of Agricultural Sciences, Quaid-e-Azam Campus, University of the Punjab, Lahore, Pakistan;2. Vegetable Research Institute, Guangdong Academy of Agriculture Sciences, Guangdong, China |
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| Abstract: | The effect of dantrolene sodium, a skeletal muscle relaxant, on drug metabolizing enzymes has been investigated after treatment of rats with a dose of 200 mg/kg for five days. We observed an induction of cytochrome P-450c and epoxide hydrolase in immunoassays and activities. An enhancement of the UDP-glucuronosyltransferase (GT1) activity was observed. We also reported a decrease of both liver cytochrome P-450 content and microsomal cytochrome P-450b dependent N-demethylation activities. On the other hand, the binding of dantrolene on microsomal cytochrome P-450 produced a type I difference spectrum, these data were obtained with liver microsomal cytochrome P-450c induced by 3-methylcholanthrene. |
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