THE SECRETION OF THYROTROPHIN WITH IMPAIRED BIOLOGICAL ACTIVITY IN PATIENTS WITH HYPOTHALAMIC–PITUITARY DISEASE |
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Authors: | V. B. PETERSEN A. M. MCGREGOR P. E. BELCHETZ R. S. ELKELES R. HALL |
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Affiliation: | Endocrine Unit, Department of Medicine, Royal Victoria Infirmary, Newcastle upon Tyne, and Clinical Research Centre, Division of Clinical Investigation, Harrow, Middlesex |
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Abstract: | We describe here two patients with hypothyroidism due to pituitary-hypothalamic disease in whom basal thyrotrophin (TSH) levels measured by radioimmunoassay (RIA) were elevated yet when measured by a cytochemical bioassay (CBA) were found to be normal. This finding and the absence of the normal rise of thyroid hormones in response to thyrotrophin-releasing hormone (TRH) mediated release of TSH confirms for the first time the secretion of TSH with impaired biological activity. Primary thyroid disease as a cause for the elevated immunoreactive TSH was excluded by the absence of circulating thyroid antibodies and by a normal thyroidal radioiodine uptake response to exogenous TSH. |
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