Uterine Leiomyoma is Associated with a Polymorphism in the Interleukin 1-β Gene期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Uterine Leiomyoma is Associated with a Polymorphism in the Interleukin 1-β Gene

Authors:	Detlef Pietrowski Roberta Thewes Michael Sator Dominik Denschlag Christoph Keck Clemens Tempfer

Institution:	Department of Obstetrics and Gynecology;Medical University Vienna, Vienna, Austria;; Fertilitaetszentrum Doebling, Austria;; Department of Obstetrics and Gynecology, Medical University Freiburg, Freiburg, Germany;; PAN-Klinik am Neumarkt, Cologne, Germany

Abstract:	Problem To investigate whether polymorphisms in the interleukin-1β (IL-1β) gene are associated with uterine leiomyoma. Method of study Case–control study in a collective of 131 patients and 280 controls. Genotyping of the IL-1β-511 and IL-1β-3954 polymorphism was performed by PCR amplification and subsequent RFLP analysis. Results A significant difference in the allele frequencies of the IL-1β-511 C Conclusion The IL-1β-511 promoter polymorphism is related to an increased susceptibility to uterine leiomyoma, suggesting that this polymorphism does contribute to the development of this disease.

Keywords:	Cytokines inflammation interleukin-1 leiomyoma polymorphism tumor