| 抗肿瘤药物埃坡霉素生物合成进展 |
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| 引用本文： | 顾勤兰,王进欣.抗肿瘤药物埃坡霉素生物合成进展[J].中国新药杂志,2005,14(10):1148-1150. |
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| 作者姓名： | 顾勤兰 王进欣 |
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| 作者单位： | 1. 中国药科大学高等职业技术学院,镇江,212003
2. 中国药科大学药化教研室,南京,210009 |
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| 摘 要： | 介绍新型抗肿瘤药物埃坡霉素在合成方面的近期发展.从埃坡霉素生物合成碳架起源与生物合成基因簇两个方向的研究结果表明,两者具有良好的一致性.与步骤繁杂的化学全合成相比,基于发酵的生物合成法更为可行.
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| 关 键 词： | 埃坡霉素 生物合成 抗肿瘤 |
| 文章编号： | 1003-3734（2005）10-1148-03 |
| 收稿时间： | 2005-09-06 |
| 修稿时间： | 2005-09-06 |
Current status of the biosynthesis of the anti-tumor agent epothilones |
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| GU Qin-lan,WANG Jin-xin.Current status of the biosynthesis of the anti-tumor agent epothilones[J].Chinese Journal of New Drugs,2005,14(10):1148-1150. |
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| Authors: | GU Qin-lan WANG Jin-xin |
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| Institution: | 1 Department of Pharmacy, Higher Vocational School, China Pharmaceutical University, Zhenjiang 212003, China ; 2 Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China |
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| Abstract: | Epothilones exhibit high antitumor activities with the same mechanism of action as Taxol and retain a much greater toxicity against p-glycoprotein overexpressing multiple drug resistant(MDR) cells.Recently a wealth of new chemistry has been developed in the biosynthesis of epothilones.This review presents recent progress in the biosyntheses of epothilones with respect to the skeleton origin and the gene cluster.Compared with the total synthetic steps,a fermentation procedure seems more feasible in the biosynthesis of epothilones. |
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| Keywords: | epothilone biosynthesis antitumor |
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