| 兴奋和损毁外侧缰核对大鼠睡眠觉醒周期的影响 |
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| 引用本文： | 桂丽,章功良,张景行,何延龙,赵乐章.兴奋和损毁外侧缰核对大鼠睡眠觉醒周期的影响[J].安徽医科大学学报,2006,41(5):511-513. |
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| 作者姓名： | 桂丽 章功良 张景行 何延龙 赵乐章 |
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| 作者单位： | 安徽医科大学生理学教研室,合肥,230032;安徽医科大学生理学教研室,合肥,230032;安徽医科大学生理学教研室,合肥,230032;安徽医科大学生理学教研室,合肥,230032;安徽医科大学生理学教研室,合肥,230032 |
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| 摘 要： | 目的 观察兴奋和损毁大鼠外侧缰核（LHb）对睡眠的影响。方法 采用脑立体定位、核团微量注射和核团损毁、多导睡眠描记技术等方法。结果 用L-谷氨酸（L—Glu）兴奋LHb时，觉醒减少，快眼动（REM）睡眠增加；而电损毁LHb时，觉醒增加，REM睡眠减少。结论 LHb参与觉醒睡眠周期的调节，其神经元兴奋具有促进REM睡眠作用。
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| 关 键 词： | 谷氨酸/药理学 神经元/生理学 睡眠/生理学 |
| 文章编号： | 1000-1492(2006)05-0511-03 |
| 收稿时间： | 2006-04-03 |
| 修稿时间： | 2006年4月3日 |
Effects of microinjection of L-glutamate into lateral habenula and lateral lesion of habenula on sleep-wake cycle |
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| Gui Li, Zhang Gongliang, Zhang Jingxing, et al.Effects of microinjection of L-glutamate into lateral habenula and lateral lesion of habenula on sleep-wake cycle[J].Acta Universitis Medicinalis Anhui,2006,41(5):511-513. |
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| Authors: | Gui Li Zhang Gongliang Zhang Jingxing |
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| Institution: | Dept of physiology, Anhui Medical University, Hefei 230032 |
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| Abstract: | Objective To assess the effects of microinjecting L-glutamate into lateral habenula and lateral lesion of habenula on sleep-wake cycle of rats. Methods Methods used in this study included stereotaxic, microjection, lesion of nucleus and polysomnography. Results Microinjection of L-glutamate into lateral habenula decreased wake time ; while increased REM sleep time. Lateral electrolytic lesion of habenula induced the contrary effects. Conclusion LHb plays an important role in the regulation of sleep-wake cycle and excitation of its neurons can improve REM sleep. |
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| Keywords: | glutamic acid/pharmacology neurons/physiology sleep/physiolgy |
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