一种简单的吸入一氧化氮的输送系统

目的　　解决国内在缺乏昂贵ＮＯ浓度监测仪的情况下应用一氧化氮吸入疗法技术的难题。方法　　１７只犬随机分为二组，吸入性损伤模型成功后，对照组单纯吸氧（ＦｉＯ２，０．４５），治疗组吸氧（ＦｉＯ２，０．４５）＋０．００４５％（４５ｐｐｍ）ＮＯ。ＮＯ输送系统由三个转子流量计分别控制 Ｏ２，Ｎ２和 ＮＯ三种气体管道出口，按需调节三股气体流量比例，在呼吸回路的吸入支置钠石灰罐。 ＦｉＯ２和二氧化氮（（ＮＯ２）数据行多个样本均间方差分析，ＮＯ行两样本均数间ｔ检验。结果ＦｉＯ２实测值比预计值高１０．８％（Ｐ＞０．０５），ＮＯ２在钻石灰处理后比钠石灰处理前降低８０．２％（Ｐ＜０．０１），ＮＯ实测值比预计值高１１％（Ｐ＞０．０５）。结论　　本系统既避免了产生过高ＮＯ２的危险，同时又克服了ＮＯ浓度不恒定的缺点，能较好地满足基础实验研究。

A Simple Delivery System of Nitric Oxide Inhalation

Objective To solve the troubles of the technique of the therapy of nitric oxide (NO) inhalation while our country lack in expensive instruments to mouiter the concentration of NO. Method Seventeen dogs were divided into two groups randomly, when the models of inhaled injury had successfully made. The control group inhaled oxygen (FiO2, 0. 45),while the treatment group inhaled oxygen (FiO2, 0. 45 ) and NO 0. 0045 % (45ppm). Depending upon the three revolver flow meters,the delivery system of NO separately controled three kinds of gas output, which included oxygen, nitrogen and NO. The proportion of three flows of gas was adjusted upon the requirement. Install a soda lime pot in the inspiratory limb of the respiratory back track FiO2 and nitrogen dioxide(NO2) were analyzed using ANOVA for multiple mean comparions, NO was analyzed by the student's t test for comparisons between two samples mean. Results The test data of FiO2 was 10. 8% higher than its expected data (P>0. 05),NO2 was 80. 2% lower while it passed through soda lime pot (P< 0. 01), the test data of NO was 11 % higher than its expected. Conclusions The system not only avoided danger of over high NO2 production,but also prevented the concentration of NO from unstablilizing. The system was likely to meet the requirement of basic experimental research.