Preparation and biodistribution of novel 99mTc(CO)3‐CNR complexes for myocardial imaging |
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| Authors: | Guiyang Hao Jianying Zang Boli Liu |
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| Affiliation: | 1. Department of Chemistry, Beijing Normal University, Beijing, People's Republic of China;2. Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan |
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| Abstract: | We evaluated lipophilicity and biodistribution of a series of 99mTc(CO)3‐ether isonitrile complexes to determine whether different lipophilicity and structure of isonitrile ligands would improve the imaging properties of the radiopharmaceutical for the heart. Novel 99mTc(CO)3‐MIBI analogs were prepared and analyzed by radio‐HPLC, and their lipophilicity was determined. These new complexes could be bi‐ or tri‐substituted in specified pH conditions like 99mTc(CO)3‐MIBI. These new complexes exhibited low liver, lungs and blood uptake compared with [99mTc(CO)3(MIBI)3]+ though their heart uptake was not so high. Among these complexes, [99mTc(CO)3(EPI)2(OH2)]+ showed higher target to non‐target ratios at 5 and 30 min post‐injection than that of [99mTc(CO)3(MIBI)3]+. Copyright © 2007 John Wiley & Sons, Ltd. |
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| Keywords: | Tc‐99m tricarbonyl isonitrile myocardial imaging |
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