Synthesis and evaluation of a water‐soluble polymer to reduce Ac‐225 daughter migration |
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Authors: | Jonathan Fitzsimmons Robert Atcher |
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Affiliation: | Bioscience Division MS M888, Los Alamos National Laboratory, Los Alamos, NM 87545, USA |
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Abstract: | The actinium decay chain has been promoted as an in vivo alpha generator for therapy, but migration of daughters from the primary conjugate has lead to increased toxicity away from the target organ. To reduce daughter migration, polyethylenimine (PEI) was used with a primary chelator and secondary chelators. The primary chelator, DOTA, was used to coordinate 225Actinium and secondary chelators‐acetate and DTPA, were added to the polymer for coordination of daughters formed by decay. The 225Actinium polymer derivatives containing secondary chelators were found to retain radioactive daughters better than the 225Actinium bond to the primary alone. The retention of 213Bismuth and 209Thallium had the following order from highest retained to lowest DOTA‐PEI‐DTPA≈DOTA‐PEI‐CH2OO‐ > DOTA‐PEI. The data suggests this polymer approach could be used to reduce daughter migration and has potential for development of actinium labeled radiopharmaceuticals. Copyright © 2007 John Wiley & Sons, Ltd. |
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Keywords: | actinium alpha therapy polyethylenimine bismuth PEI daughter retention |
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