Age-associated increase of 8-hydroxydeoxyguanosine in human colorectal tissue DNA. |
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| Authors: | Y Tsurudome T Hirano K Hirata A Higure N Nagata K Takahashi H Itoh H Kasai |
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| Institution: | Departments of Environmental Oncology, University of Occupational and Environmental Health, Kitakyushu, Japan. |
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| Abstract: | To clarify the role of oxidative stress in aging of colorectal tissue, we analyzed the 8-hydroxydeoxyguanosine (8-OH-dG) levels in colorectal biopsy samples from normal tissue of patients with either colorectal cancer (n = 15) or benign colorectal polyps (n = 40). An age-associated increase of 8-OH-dG was observed (p =.002), although the 8-OH-dG levels were not significantly different between the patients with cancer and those with polyps. These results suggest an increased level of 8-OH-dG formation in human colorectal tissue with age. |
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