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A large-scale outbreak of hand,foot and mouth disease,France, as at 28 September 2021
Authors:Audrey Mirand,Robert Cohen,Maxime Bisseux,Sté  phanie Tomba,Fabienne Cahn Sellem,Nathalie Gelbert,Sté  phane Bé  chet,Bruno Frandji,Christine Archimbaud,Amé  lie Brebion,Hé    ne Chabrolles,Christel Regagnon,Corinne Levy,Jean-Luc Bailly,Cé  cile Henquell
Abstract:We report a large-scale outbreak of hand, foot and mouth disease (HFMD) in France. As at 28 September 2021, 3,403 cases have been reported (47% higher than in 2018–19). We prospectively analysed 210 clinical samples; 190 (90.5%) were enterovirus-positive. Most children presented with atypical HFMD. Coxsackievirus (CV)A6 (49.5%; 94/190) was predominant; no enterovirus A71 was detected. Dermatological and neurological complications of HFMD justify prospective syndromic and virological surveillance for early detection of HFMD outbreaks and identification of associated types.
Keywords:enterovirus   paediatric infectious diseases surveillance   herpangina   hand   foot and mouth disease   syndromic surveillance   ambulatory network
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