Intra-hemispheric alpha coherence decreases with increasing cognitive impairment in HIV patients |
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| Affiliation: | 1. Institute of Volcanology and Seismology, Russian Academy of Sciences, Petropavlovsk-Kamchatsky 683006, Russia;2. Institute of Geophysics, Universidad Nacional Autónoma de México, Coyoacán, México D.F., 04510, Mexico;1. “Dr. Victor Babes” Hospital for Infectious and Tropical Diseases, Bucharest, Romania;2. University of California San Diego, La Jolla, CA, USA;3. “Stefan S. Nicolau” Institute of Virology, Bucharest, Romania;1. Division of Translational Medicine, Research Branch, Sidra Medicine, Doha, Qatar;2. Department of Radiology and Imaging, Fortis Memorial Research Institute, Gurgaon, India;3. Department of Neurology, King George Medical University, Lucknow, India;4. Department of Microbiology, King George Medical University, Lucknow, India;5. Department of Pediatric Gastroenterology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India;6. Department of Psychiatry, Sidra Medicine/Weill Cornell Medicine-Qatar, Doha, Qatar;7. Laboratory Animal Research Center, Qatar University, Doha, Qatar;1. The Faculty of Psychology, University of Warsaw, Stawki 5/7, 00-183 Warsaw, Poland;2. The Department of Biomedical Engineering, New Jersey Institute of Technology, University Heights Newark, NJ 07102, USA;3. Institute of Physiology and Pathology of Hearing, World Hearing Center, Mokra 17, Kajetany, 05-830 Nadarzyn, Poland;4. The Cleveland Clinic, 9500 Euclid Ave., Cleveland, OH 44195, USA;5. The College of Medicine, The Ohio State University, 370 W. 9th Ave., Columbus, OH 43210, USA;6. The Central Hospital for Infectious Diseases, Wolska 37, 01-201 Warsaw, Poland;7. The Department of Psychiatry, Medical University of Warsaw, Żwirki i Wigury 61, 00-001 Warsaw, Poland;8. The Institute of Psychiatry and Neurology, Sobieskiego 9, 02-957 Warsaw, Poland |
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| Abstract: | Inter-hemispheric and intra-hemispheric canonical coherences in the alpha range between EEG signals collected from frontal and posterior groups of electrodes were estimated for 38 HIV positive subjects and 23 uninfected controls. Neuropsychological testing was used to categorize the degree of cognitive impairment evident in each of the subjects. A linear regression analysis provided evidence that intra-hemispheric coherence decreased with increasing cognitive impairment in impaired HIV+ subjects, as measured by a Global Impairment Score (GIS). There was no evidence that cognitively unimpaired HIV+ subjects differed in coherence when compared to uninfected control subjects. Severely impaired HIV+ subjects showed significantly decreased coherence compared to uninfected controls. These data contradict previous work demonstrating increased intra-hemispheric and inter-hemispheric alpha coherence in impaired HIV subjects. In addition, they provide evidence that intra-hemispheric (and possibly inter-hemispheric) disconnection is associated with cognitive impairment in HIV. |
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