Sialidase activity of oncogenic cells transformed by herpes simplex virus |
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Authors: | C L Schengrund R Duff A Rosenberg |
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Affiliation: | Departments of Biological Chemistry and Microbiology, The Milton S. Hershey Medical Center, The Pennsylvania State University, Hershey, Pennsylvania 17033 USA |
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Abstract: | Sialidase in normal nononcogenic hamster embryo fibroblasts was not active toward added disialo- and trisialoganglioside, but all transformed lines of hamster embryo fibroblasts studied had sialidase active toward added ganglioside substrate. The levels of exogenous sialidase activity suggested a parallel trend in the amount of this activity and the degree of oncogenicity of the transformed cells. Exogenous sialidase activity in a weakly oncogenic cell line was found to increase after passage of the cells into hamsters and isolation and cell culture of the resulting tumors which gave rise to a cell line of relatively high oncogenicity. |
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