THE EFFECT OF CHOLESTEROL OXIDATION PRODUCTS ON HUMAN PLATELET AGGREGATION |
| |
| Authors: | Michael L Selley Julie A McGuiness Neville G Ardlie |
| |
| Institution: | Cardiovascular Disease Group, Division of Clinical Sciences, The John Curtin School of Medical Research, The Australian National University, Woden Valley Hospital, Garran, A.C.T., 2605, Australia |
| |
| Abstract: | The cholesterol oxidation products (oxysterols) cholest-3,5-diene-7-one, cholestan-5 , 6-epoxy-3β-ol (cholesterol 5-epoxide), cholestan-5β,6β-epoxy-3β-ol (cholesterol 5β-epoxide), cholest-5-ene-3β-ol-7-one (7-ketocholesterol), cholest-5-ene-3β,7-diol (7-hydroxycholesterol), cholestan-3β,5,6β-triol (choestane triol), and cholest-5-ene-3β,26-diol (27-hydroxycholesterol) potentiated platelet aggregation and increased thromboxane A2 formation in platelets challenged with thrombin, ADP or collagen. These effects were observed at oxysterol concentrations in the range 5–100 μM. Cholesterol 5β-epoxide and 7-ketocholesterol increased the mobilization of 3H-arachidonic acid from prelabelled platelet phospholipids in response to thrombin and collagen. |
| |
| Keywords: | thrombocyte aggregation cholesterol cholesterol derivative 7 oxocholesterol |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
