| 失神经对大鼠面肌NT-3 mRNA表达影响的实验研究 |
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| 引用本文： | 陈传好,王震寰,陈昌杰,秦登友,曹承亮.失神经对大鼠面肌NT-3 mRNA表达影响的实验研究[J].四川解剖学杂志,2004,12(2):95-97. |
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| 作者姓名： | 陈传好 王震寰 陈昌杰 秦登友 曹承亮 |
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| 作者单位： | 1. 蚌埠医学院解剖教研室
2. 蚌埠医学院临床生化教研室,蚌埠,233003 |
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| 摘 要： | 目的 检测神经营养素3(neurotrophin-3，NT-3)mRNA在大鼠的面肌和失神经的面肌内的表达。方法离断大鼠面神经的下颌缘支和颊支制备面神经损伤模型。在损伤后的第7天，采用RT-PCR技术检测NT-3mRNA在面肌和失神经的面肌内表达。结果 失神经的面肌未检测到NT-3mRNA，有神经支配的面肌内有NT-3mRNA的表达。结论 NT-3mRNA在靶器官的表达可能是受其支配的神经控制。
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| 关 键 词： | 失神经 大鼠 面肌 NT-3 mRNA表达 实验 神经营养素3 周围神经损伤 |
Study on Neurotrophin-3 mRNA Expression in Denervation Facial Muscles of Rats |
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| Cheng Chuan hao,Wang Zhen huan,Chen Chang jie et al.Study on Neurotrophin-3 mRNA Expression in Denervation Facial Muscles of Rats[J].Sichuan Journal of Anatomy,2004,12(2):95-97. |
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| Authors: | Cheng Chuan hao Wang Zhen huan Chen Chang jie |
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| Institution: | Cheng Chuan hao1;Wang Zhen huan;Chen Chang jie et al Department of anatomy of Bengbu medical college Bengbu 233003 China |
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| Abstract: | Obejective To detect the NT-3(neurotrophin-3) mRNA expression in the
denervation and innervation facial muscles of rats. Methods The model of facial nerve le-
sion was established in rats by cutting the marginal madibular branch and buccal branches
of facial nerve. RT-PCR was employed to confirm whether NT-3 mRNA expressed in the
denervation and innervation facial muscles of rats 7 days after lesion. Results Compared
with NT-3 mRNA expression in the innervation facial muscles of rats, the NT-3. mRNA
expression were not detected in the denervation facial muscles of rats. Conclusion the
NT-3 mRNA expression in target organs was possibly controlled by neurons factor. |
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| Keywords: | neurotrophin-3 denervation facial muscles RT-PCR |
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