神经肽Y拮抗去甲肾上腺素在杏仁核的心血管效应

为了解杏仁内侧核内神经肽Ｙ（ＮＰＹ）和去甲肾上腺素（ＮＡ）的相互关系，向杏仁内侧核（ＭＡＮ）内微量注射ＮＰＹ，或微电泳ＮＰＹ，观察神经元单位放电和测量动脉血压，并在血压改变的条件下测量血浆中ＮＡ含量。结果发现，ＮＰＹ可以对抗ＮＡ的升压作用，微电泳ＮＰＹ到ＭＡＮ也得到相同结论。向ＭＡＮ注入ＮＰＹ后血浆中ＮＡ的含量明显减少，这可能是ＮＰＹ拮抗ＮＡ作用的原因之一。

NPY antagonizes the Cardiovascular effects induced by norepinephrine in amygdaloid nucleus

The goal of the present experiments was to delineate the cardiovascular functions of NPY in brain and the action of it with the cooperation of NA in the cardiovascular regulation.Wistar adult rats were used.NPY and NA were dissolved in saline(0 3μl)and injected into MAN through the cannula pernetrated by the direction of stereotaxic apparatus.The extracellular discharges were recorded with the glass microelectrodes,and the microionophoresis experiments were completed with four multielectrode.The volume of CA in the blood were assayed by the method of HLC.The results are as follows:Microinj ection of NA into MAN induced the pressor effect and the increase of the heart rate.When NPY was injected into MAN,the decrease of blood pressure and heart rate were observed.If the dosage of NPY itself was used,which never induced any changes of the indexes assayed in the experiment,but could inhibit the pressor effect induced by injected NA.That was a clue of the cooperation of NPY and NA in the central regulation of cardiovascular activities.