不同孕期孕妇血清α-L-岩藻糖苷酶(AFU)标准值研究测定及其对正常妊娠临床价值

目的:测定不同孕周孕妇血清中α-L-岩藻糖苷酶(AFU)含量,明确正常妊娠AFU的标准值及其对正常妊娠的临床意义。方法:对早孕组(孕12周末以前)、中孕组(孕13~27周末以前)、晚孕组(孕28~41周)共2 583例,非孕期对照组妇女136例,空腹抽取静脉血2 m l,离心分离血清,应用速率法检测血清AFU值。数据以均数±标准差表示,两均数差别采用独立样本t检验;用SPSS 10.0统计软件。组间比较采用非参数检验方法即Kruskal-W allis Test。结果:早孕组AFU正常值范围在10.800~37.070 U/L,与非孕期对照组无显著性差异。中孕组、晚孕组正常值分别为13.950~46.170 U/L、24.195~61.100 U/L,与非孕期对照组间存在显著性差异。结论:随着孕周的增加,孕妇血清AFU含量显著升高,期望不同孕期孕妇血清AFU标准值的确定,对正常妊娠及病理妊娠提供有价值的诊断指标。

Measurement and significance of α-L-Fucosidase(AFU)in different weeks of pregnant women

Objective:To meansure α-L-fucosidase(AFU) in different weeks of pregnancy women,and to establish their standard level of AFU.Methods:Detect AFU level from four groups of women:688 women of early pregnancy group(<13 weeks),658 women of middle pregnancy group(13~27 weeks),1 237 women of later pregnancy group(28~41 weeks)and 136 non-pregnancy womenas control group.Results:Normal level of AFU was between 10.800～37.070 U/L in early pregnancy group(<16 weeks),there was no significant difference between early pregnancy group and non-pregnancy group.Normal levels of AFU was between 13.950～46.170,24.195～61.100 U/L in middle pregnancy group(16~37 weeks) and in later pregnancy group respectively,there were signicicant difference between middle and later pregnancy groups compared with non-pregnancy group.Conclusion:Levels in serum of pregnancy women increases with pregnancy weeks significantly,which would be good help in diagnosis of normal and abnormal pregnancy.