高温对溃疡大鼠胃窦粘膜胃泌素、生长抑素及胃动素的影响

目的　研究高温对溃疡大鼠胃窦粘膜胃泌素、生长抑素及胃动素的影响。方法　42只Wistar大鼠随机分为6组,以冰乙酸注入大鼠胃窦前壁制作胃溃疡模型,放免法检测动物在不同温度下胃窦粘膜的胃泌素、生长抑素、胃动素水平。结果　胃溃疡后胃窦粘膜胃泌素、胃动素水平上升,生长抑素水平下降。高温溃疡组的溃疡后胃窦粘膜胃泌素、胃动素上升幅度较适温对照组的上升幅度减小,高温溃疡组的溃疡后胃窦粘膜生长抑素下降幅度较适温对照组的下降幅度减小。结论　高温会对胃溃疡大鼠胃窦粘膜的胃泌素、生长抑素、胃动素含量产生影响。

Effect of high temperature on gastrin, somatostatin and motdin production in ulcerous gastric antral mucosa of rats

Objective To investigate the changes of gastrin, somatostatin and motilin production in the gastric anttal mucosa of rats with experimental gastric ulcer. Methods Rat models of gastric ulcer model were induced successfully by injection of acetic acid into the gastric antral wall of 2 groups of Wistar rats (7 in each group) that were subjected to enviroment of either high or normal temperature. Another 2 groups of rats (n=7) receiving normal saline injection in the same manner, along with still another 2 groups (n=7) without any treatment, all of which were kept under conditions with different temperatures accordingly, constituted the control groups. The levels of gastrin, somatostatin and motilin in the gastric antral mucosa of the rats were measured with radioimmunoassay. Results In rats with gastric ulcer, the levels of gastrin and motilin in the antral mucosa increased, but in a lesser scale in rats with ulcer kept in high temperature than in normal temperature group, while that of somatostatin was reduced. The level of somatostatin declined less in the high temperature group with ulcer than in the normal temperature group with ulcer. Conclusion High temperature can affect gastrin, somatostatin and motilin production in the gastric antral mucosa of rats with gastric ulcer.