首页 | 本学科首页   官方微博 | 高级检索  
     


Terlipressin (Triglycyl-Lysine Vasopressin) Controls Acute Bleeding Oesophageal Varices: A Double-Blind,Randomized, Placebo-Controlled Trial
Abstract:The haemostatic effect of terlipressin (triglycyl-lysine vasopressin; Glypressin®) on bleeding from oesophageal varices was evaluated in a placebo-controlled, double-blind, randomized clinical trial. Patients with clinically suspected liver cirrhosis were included in the study if they had been admitted to hospital with an extensive haemorrhage within the last 24 h before diagnostic endoscopy. The patients randomized after stratification for severity of liver disease. Terlipressin or placebo was administered as intravenous bolus injections every 4th h during a period of 24 to 36 h or until the clinical course necessitated active intervention (failure or withdrawal). Sixty patients entered the study; 31 patients were allocated to receive terlipressin, and 29 patients to receive placebo. Bleeding from varices was arrested in 28 of the 31 receiving terlipressin, as compared with 17 of the 29 receiving placebo (p < 0.01). Patients receiving active drug required significantly fewer blood transfusions (p < 0.05). Most of the side effects were classified as mild and were registered in the terlipressin group.
Keywords:Gastrointestinal bleeding  haemostasis  liver cirrhosis  oesophageal varices  terlipressin (Glypressin®)  vasopressin
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号