Tenascin—C在肾癌中的表达及临床意义 |
| |
引用本文: | 鲁友谊,周荣祥,白岚.Tenascin—C在肾癌中的表达及临床意义[J].康复与疗养杂志,2010(2):120-121,124. |
| |
作者姓名: | 鲁友谊 周荣祥 白岚 |
| |
作者单位: | [1]青岛大学医学院附属青岛市立医院泌尿外科,山东青岛266011 [2]中国人民解放军第71497部队,山东青岛266011 |
| |
摘 要: | 目的探讨Tenasdn-C(TN—C)在肾癌组织中的表达及临床意义。方法应用免疫组织化学方法检测不同分级的56例肾癌、15例正常肾组织TN—C的表达,分析TN—C与临床病理因素及预后之间的关系。结果肾癌组织TN—C阳性表达率为53.6%(30/56),正常肾组织未检出TN—C阳性表达,两者比较差异有统计学意义(χ^2=7.780,P〈0.01)。TN—C的表达随着癌组织病理学分级、临床分期的增加而增加(P=0.002—0.041);TN—C阳性表达组与阴性表达组之间的生存率比较差异有统计学意义(χ^2=6.711,P〈0.05)。结论TN-C的表达与肾癌发生、发展及预后有密切的关系。
|
关 键 词: | 肾肿瘤 Tenascin-C 免疫组织化学 |
EXPRESSION OF Tenascin-C IN RENAL CARCINOMA AND ITS CLINICAL SIGNIFICANCE |
| |
Authors: | LU YOU-YI ZHOU RONG- XIANG BAILAN |
| |
Institution: | (Department of Urology, The Affiliated Qingdao Municipal Hospital of Qingdao University Medieal College, Qingdao 266011, China) |
| |
Abstract: | Objective To investigate the expression of Tenascin-C (TN-C) in renal carcinoma and its clinical significance. Methods The expressions of TN-C in 56 cases of different-grade renal carcinoma and 15 of normal renal tissue were detected im- munohistochemically, The correlation of TN-C with clinical pathology and prognosis of the cancer was analyzed. Results The positive rate of TN-C expression in the cancer was 53.6% (30/56), no TN-C was detected in normal renal tissue. The difference of TN-C expression between the two groups was significant (χ^2=7. 780,P〈0.01). The expression of TN-C increased with the increase of pathologic grading and clinical staging (P=0. 002-0. 041). The survival was significantly related with the expression of TN-C (χ^2 =6. 711,P〈0.05). Conclusion The expression of tenascin-C is significantly related to the develonment. progression and prognosis of renal carcinoma. |
| |
Keywords: | kidney neoplasms Tenascin-C immunohistochemistry |
本文献已被 维普 等数据库收录! |