心绞痛病人血清炎性因子的变化及其临床意义

目的探讨炎性因子在心绞痛发生与发展中的变化及其临床意义。方法将60例经冠状动脉造影检查确诊为冠心病心绞痛病人分为稳定型心绞痛（SAP）组28例和不稳定型心绞痛（UAP）组32例,采用GC-911γ计数仪测定法、免疫散射比浊法测定其血清白细胞介素（IL）-6I、L-8、肿瘤坏死因子α（TNF-α）、高敏C反应蛋白（hs-CRP）水平及外周血白细胞（WBC）数量,并以20例健康人作为对照组。结果与对照组比较,心绞痛病人血清中IL-6I、L-8、TNF-α、hs-CRP含量及WBC数均升高（t=2.986～6.069,P〈0.01）,且UAP组IL-6I、L-8、TNF-α、hs-CRP含量及WBC数高于SAP组（t=2.163～3.255,P〈0.05、0.01）。UAP组病人的hs-CRP与IL-6及WBC呈正相关（r=0.376、0.366,P〈0.05）,SAP组病人的hs-CRP与WBC呈正相关（r=0.515,P〈0.01）。结论炎症反应参与心绞痛的发生及发展,监测炎性因子水平变化可为临床病情分级和预后判断提供一定参考。

CHANGES AND CLINICAL SIGNIFICANCE OF INFLAMMATORY FACTORS IN PATIENTS WITH ANGINA PECTORIS

Objective To explore the changes and clinical significance of inflammatory factors in the occurrence and development of angina pectoris. Methods Sixty patients with coronary heart disease（CHD） accompanying angina confirmed by coronary arteriography（CAG）,of whom,28 were assigned to stable-angina（SA） group and 32 to unstable angina（UA） group.The serum interleukin（IL）-6,8,tumor necrosis factor-α（TNF-α）,high-sensitivity C-reactive protein（hs-CRP） were measuredusing GC-911 γ counter assay and immune scattering ratio turbidimetric technique,and white blood cells（WBC） of peripheral blood were detected as well.Twenty healthy subjects served as controls. Results Compared with the controls,the serum levels of inflammatory cytokines（IL-6,IL-8,TNF-α,hs-CRP） and WBC in patients with angina elevated（t=2.986-6.069;P0.01）,and that in patients in UA group were higher than those in SA group（t=2.163-3.255;P0.05,0.01）.The hs-CRP and IL-6 as well as WBC in UA group were positively correlated（r=0.376,0.366;P0.05）,and the hs-CRP was positively correlated with the WBC in SA group（r=0.515,P0.01）. Conclusion Inflammatory response involves in the occurrence and development of angina.A monitoring of the levels of inflammatory indicators is of a certain value of reference for clinical classification and prognostic prediction of this condition.