脑卒中病人血浆溶血磷脂分子含量的变化

目的观察脑出血与脑梗死病人血浆溶血磷脂分子含量变化的特点，探究其病理生理机制。方法选取经临床和辅助检查确诊的脑出血病人68例、脑梗死病人80例，测定其发病24h和1周时血浆溶血磷脂酸（LAP）及相似磷脂（AP）的含量。以年龄匹配的健康体检者70例作为对照组。结果发病24h时，脑梗死组血浆LPA与AP含量高于对照组和脑出血组，差异有显著性（t=3．54～6．51，P〈0．01）；发病1周时，脑出血组血浆LPA与AP含量高于对照组和脑梗死组，差异均有显著性（t=4．71～7．82，P〈0．01）。结论脑出血与脑梗死发生脑损伤的病理生理机制不同，两者治疗应采取不同的策略。

CHANGES OF PLASMA LEVELS OF LYSOPHOSPHOLIPID IN PATIENTS WITH BRAIN HEMORRHAGE AND CEREBRAL INFARCTION

Objective To investigate the changes of plasma lysophospholipid （LPL） in patients with brain hemorrhage （BH） and cerebral infarction （CI） and explore the pathophysiologic mechanism of the disease. Methods Sixty-eight patients with BH and 80 with CI were enrolled in this study. The plasma lysophosphatidic acid （LPA） and acidic phospholipids （AP） were detected at 24 hour and one week after the onset. Seventy age-matching healthy subjects served as a control group. Results At 24 h after the onset, the levels of plasma LPA and AP in CI group were significantly higher than that in BH and control groups （t=3.54 -6.51 ,P〈0.01） ; One week after the onset, the levels of LPA and AP in BH group were higher than that in the CI and control （t=4.71-7.82,P〈0.01）. Conclusion The pathophysiologie machenism of brain hemorrhage and cerebral infarction is different, and different therapies should be offered accordingly.