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FLAG方案治疗难治及复发性急性髓性白血病的效果
引用本文:王朝晖,韩波,范传波,王九河,洪青,刘俊玲,乌庆超.FLAG方案治疗难治及复发性急性髓性白血病的效果[J].康复与疗养杂志,2010(6):485-486.
作者姓名:王朝晖  韩波  范传波  王九河  洪青  刘俊玲  乌庆超
作者单位:青岛市海慈医院血液科,山东青岛266033
摘    要:目的 观察氟达拉宾+阿糖胞苷+粒细胞集落刺激因子方案(FLAG方案)治疗难治及复发性急性髓性白血病的效果.方法 采用FLAG方案治疗难治及复发性急性髓性白血病20例.结果 完全缓解8例(40%),部分缓解4例(20%),未缓解5例,死亡3例,有效率60%.主要副作用为胃肠道反应和骨髓抑制.结论 FLAG方案治疗难治及复发性急性髓性白血病效果较好.

关 键 词:白血病  粒细胞  急性  氟达拉宾  阿糖胞苷  粒细胞集落刺激因子  治疗结果

FLUDARABINE, CYTARABINE AND G-CSF REGIMEN IN THE TREATMENT OF RELAPSED AND REFRACTORY ACUTE MYELOID LEUKAEMIA
Institution:WANG ZHAO-HUI,HAN BO,FAN CHUAN-BO(Department of Hematology, Qingdao Haici Hospital, Qingdao 266033, China)
Abstract:Objective To evaluate combo therapy with fludarabine, cytarabine, and G-CSF (FLAG) for relapsed and refractory acute myeloid leukaemia (AML). Methods The combo therapy of FLAG was applied in the treatment of 20 patients with relapsed and refractory AML. Results Eight (40%) patients achieved complete remission (CR), and four (20%) partial remission, non-remission five, and death three, the effective power being 60%. The main side effects were gastrointestinal tract reactions and bone marrow depression. Conclusion FLAG therapy is effective for relapsed and refractory acute myeloid leukae- mia.
Keywords:leukemia  myelocytic  acute  fludarabine  cytarabine  granuiocyte colony-stimulating factor  treatment outcom
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