Polymer incorporation method affects the physical stability of amorphous indomethacin in aqueous suspension |
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Institution: | 1. School of Pharmacy, University of Otago, Dunedin, New Zealand;2. Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Finland;3. Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark;1. Laboratório de Controle de Qualidade de Fármacos e Medicamentos (LabCQ), Programa de Pós-Graduação em Farmácia, Departamento de Ciências Farmacêuticas, Universidade Federal de Santa Catarina, 88040-900, Florianópolis, SC, Brazil;2. Laboratório de Polímeros e Surfactantes da UFSC (POLISSOL), Departamento de Química, Universidade Federal de Santa Catarina, 88040-900, Florianópolis, SC, Brazil;3. Grupo de Estudos em Materiais Poliméricos (POLIMAT), Departamento de Química, Universidade Federal de Santa Catarina, 88040-900, Florianópolis, SC, Brazil;1. Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, Viikinkaari 5 E, 00014 Helsinki, Finland;2. Orion Pharma R&D, Global Pharmaceutical Research, P.O. Box 65, 02101 Espoo, Finland |
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Abstract: | This study reports the potential of different polymers and polymer incorporation methods to inhibit crystallisation and maintain supersaturation of amorphous indomethacin (IND) in aqueous suspensions during storage. Three different polymers (poly(vinyl pyrrolidone) (PVP), hydroxypropyl methylcellulose (HPMC) and Soluplus® (SP)) were used and included in the suspensions either as a solid dispersion (SD) with IND or dissolved in the suspension medium prior to the addition of amorphous IND. The total concentrations of both IND and the polymer in the suspensions were kept the same for both methods of polymer incorporation. All the polymers (with both incorporation methods) inhibited crystallisation of the amorphous IND. The SDs were better than the predissolved polymer solutions at inhibiting crystallisation. The SDs were also better at maintaining drug supersaturation. SP showed a higher IND crystallisation inhibition and supersaturation potential than the other polymers. However, this depended on the method of addition. IND in SD with SP did not crystallise, nor did the SD generate any drug supersaturation, whereas IND in the corresponding predissolved SP solution crystallised (into the recently characterised η polymorphic form of the drug) but also led to a more than 20-fold higher IND solution concentration than that observed for crystalline IND. The ranking of the polymers with respect to crystallisation inhibition potential in SDs was SP ≫ PVP > HPMC. Overall, this study showed that both polymer type and polymer incorporation method strongly impact amorphous form stability and drug supersaturation in aqueous suspensions. |
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Keywords: | Amorphous Suspension Polymer Stabilisation Solid dispersion Physical stability Crystallisation Dissolution Solubility Indomethacin |
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