光动力疗法治疗老年黄斑变性临床初步观察

目的　观察应用光动力疗法 (photodynam ic therapy,PDT )单次治疗渗出型年龄相关性黄斑变性 (age- related m acu-lar degeneration,A MD )并发脉络膜新生血管 (choroidal neovascularization,CN V )的近期治疗效果。方法　以眼底检查、视力、眼底荧光血管造影 (FFA)、吲哚青绿脉络膜血管造影 (ICG)和光学相干断层成像技术 (O CT)等影像学检查为观察指标 ,总结PDT治疗 15例 16眼 A MD合并的典型 CNV后 1周和 1个月随访的短期治疗效果 ,从而评价 PDT治疗 CNV的安全性和短期治疗效果。结果　治疗后 1周和 1个月分别有 6眼和 10眼视力不同程度提高 ,1眼因新出血视力略有下降 ,无证据表明与治疗有关。 15例 16眼治疗后荧光渗漏均有不同程度的减弱或消退 ,其中 7例 8眼渗漏完全消退 ,1月后复查无复发 ;其余 8例8眼荧光渗漏明显减轻。全部 15例治疗过程中未发生任何不良反应 ;仅 3例治疗后主述有一过性轻度视力紊乱。结论　光动力疗法单次治疗渗出型年龄相关性黄斑部变性并发的脉络膜新生血管膜短期疗效满意、安全 ,对视力无损害。

Clinical primary study of photodynamic therapy for wet age-related macular degeneration

Objective To evaluate short-term effects of a single photodynamic therapy (PDT) treatment for choroidal neovascularization(CNV) in age-related macular degeneration(AMD). Methods Fifteen cases(16 eyes) who were diagnosted as AMD patients with classic CNV were treated with PDT. The data of ophthalmic examination,visual acuity testing,color photography,optic coherence tomography,fluorescein angiograms and indocyanine green angiogram before treatment, and 1 week and 1 month after treatment were used to evaluate the effects of a single PDT treatment. Results The visual acuity of 6 eyes and 10 eyes were improved respectively at the 1 week and 1 month follow-up. The visual acuity of 1 eye was reduced caused by new-hemmoregy non-related with the treatment. Distinct reduction or disappearance of fluorescein leakage from CNV was noted in all patients. No serious complications occurred. Conclusion Short-term effects of a single PDT treatment for CNV in AMD is effective and safe and causes no loss of vision.