| 细胞毒T细胞 |
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| 作者姓名： | Ma G Zhu LP Zhang W |
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| 作者单位： | 1. 中国协和医科大学临床医学98级,北京,100730
2. Department of Immunology, Institute of Basic Medical Sciences, CAMS and PUMC, Beijing,100005 |
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| 摘 要： | 细胞毒T细胞(CTL)分为CD8 CTLs、CD4 CTLs和CD4-CD8-CTLs几个亚群,它来源于淋巴样造血干细胞的T细胞库,在胸腺中发育成熟,并在周围淋巴组织中活化。效应CTL对靶细胞实行杀伤的途径主要有两条:FasL-Fas介导的细胞凋亡作用和颗粒胞吐途径介导的溶细胞作用。由于CTL在抗肿瘤和抗病毒中效应显著,因而受到广泛重视。
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| 关 键 词： | 细胞毒T细胞 Fas/FasL 颗粒酶 穿孔素 |
| 修稿时间： | 2002年5月14日 |
Cytotoxic T cell |
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| Ma G,Zhu LP,Zhang W.Cytotoxic T cell[J].Acta Academiae Medicinae Sinicae,2002,24(4):439-442. |
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| Authors: | Ma Ge Zhu Li-ping Zhang Wei |
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| Institution: | Department of Clinical Medicine, PUMC, Beijing 100730, China. |
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| Abstract: | Department of Immunology,Institute of Basic Medical Sciences,CAMS and PUMC,Beijing100005 Cytotoxic T cell(CTL)covers several subtypes,which are CD8 ,CD4and CD4 - CD8 - .CTL derives from T cell repertoire in lymphoid hematopoietic stem cells.It matures in thymus and is activated in peripheral lymphoid tissues.Effector CTL kills the target cells by2ways.One is apoptotic effect mediated by FasL-Fas pathway and the other one is cytolytic effect mediated by granzymes.CTL has aroused great attention due to its significance in anti-tumor and anti-virus. |
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| Keywords: | cytotoxic T cell FasL-Fas granzyme perforin |
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