幽门螺杆菌阳性的十二指肠球部溃疡出血患者根除治疗对再出血的影响

目的探讨幽门螺杆菌（Hp）阳性的十二指肠球部溃疡（DU）出血患者根除Hp治疗与否对DU出血复发的影响。方法96例Hp阳性DU出血患者，随机分为治疗组（40例）与对照组（56例）。治疗组口服奥美拉唑20m（d＋丽珠胃三联1盒／d，共7d；对照组仅口服奥美拉唑20mg/d，共28d。治疗结束后1月复查内镜及Hp。随访2年。结果治疗组Hp阴转率95．0％（38／40），对照组35．7％（20／56），2组比较差异有统计学意义（χ^2=8．228，P〈0．01）；治疗组溃疡愈合率100．0％（40／40），对照组94．6％（53／56），2组比较差异无统计学意义（χ^2=0．035，P〉0．05）；2年内随访，治疗组再出血率5．0％（2／40），对照组32．1％（18／56），2组比较差异有统计学意义（χ^2=7．186，P〈0．01）。结论对Hp阳性的DU出血患者，Hp根除治疗后可有效预防再出血。

The impact of eradicating H.Pylori on recurring of haemorrhage in patients with H. Pylori positive duodenal ulcer haemorrhage

Objective To observe the influence of Helieohaeter pylori（Hp） eradication on recurring of duodenal ulcer（DU） with Hp positive haemorrhage. Methods Ninety-six patients with DU infected by Hp were randomly divided into treatment group（40 cases） and control group （56 cases）. The treatment group administered omeprazole 20 mg/d for 7 days and Lizhuweisaulian 1 box （8 tablets）/d for 7 days. The control group were only dosed omeprazole 20 mg/d for 28 days. Hp infection conditions of all patients were detected 1 month later,and all patients had been followed-up for 2 years. Results Hp eradication rates were 95.0% （38/40） and 35.7% （20/56） in treatment group and control group respectively, and the difference was significant （χ^2 = 8. 228, P 〈 0. 01 ）. DU heal rates were 100. 0% （40/40） and 94. 6 % （53/56） in treatment group and control group respectively with no significant differenee（χ^2 = 0. 035, P 〉 0. 05）. The recurring rates of DU haemorrhage were 5.0% （2/40） and 32. 1% （ 1/56 ） in treatment group and control group respectively with significant difference （χ^2 = 7. 186, P 〈 0. 01 ）. Condusions Eradicating Hp can effectively prevent recurring of Hp positive DU haemorrhage.