|
|||||
|
|
Parvalbumin-containing interneurons in rat hippocampus have an AMPA receptor profile suggestive of vulnerability to excitotoxicity |
|
| Authors: | Moga Diana Hof Patrick R Vissavajjhala Prabhakar Moran Thomas M Morrison John H |
| Affiliation: | a Kastor Neurobiology of Aging Laboratories, Mount Sinai School of Medicine, Box 1639, One Gustave L. Levy Place, New York, NY 10029-6574, USA b Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York, NY, USA c Department of Microbiology, Mount Sinai School of Medicine, New York, NY, USA |
| Abstract: | -Amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptors mediate excitatory neurotransmission in the central nervous system, and contain combinations of four subunits (GluR1-4). We developed a GluR3-specific monoclonal antibody and quantified the cellular distribution of GluR3 in rat hippocampus. GluR3 immunoreactivity was detected in all pyramidal neurons and most interneurons. In addition, we found a subset of parvalbumin (PV)-containing interneurons in the hippocampus and neocortex that was notable for its intense GluR3 immunoreactivity and lack of GluR2 immunoreactivity. Such an expression pattern of AMPA receptor subunits is likely to make these interneurons selectively vulnerable to excitotoxicity. |
| Keywords: | Excitatory amino acids GluR3 Interneurons |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ | |