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Role of beta-lactamase in expression of resistance by methicillin-resistant Staphylococcus aureus. |
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| Authors: | J M Boyce and A A Medeiros |
| Abstract: | Of 27 unique clinical isolates of methicillin-resistant Staphylococcus aureus, only 4 were homogeneously resistant, and all 4 produced little or no beta-lactamase. Among heterogeneously resistant strains, those most resistant to beta-lactam antibiotics produced the most beta-lactamase. Similar genes may regulate production of the low-affinity penicillin-binding protein and beta-lactamase. |
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