| 链球菌组蛋白样蛋白对小鼠腹腔巨噬细胞产生IL-6的影响 |
| |
| 引用本文： | 沈海中,张力平,平国玲,张红春,靖学芳,李郁英,李玉兰,李卫红,张海燕.链球菌组蛋白样蛋白对小鼠腹腔巨噬细胞产生IL-6的影响[J].首都医学院学报,2003,24(1):11-13. |
| |
| 作者姓名： | 沈海中 张力平 平国玲 张红春 靖学芳 李郁英 李玉兰 李卫红 张海燕 |
| |
| 作者单位： | [1]首都医科大学免疫学系 [2]首都医科大学细胞生物系 |
| |
| 基金项目： | 北京市自然科学基金资助项目 ( 7992 0 0 3 ) |
| |
| 摘 要： | 为研究链球菌组蛋白样蛋白 (HlpA)对小鼠腹腔巨噬细胞 (MΦ)体外产生白细胞介素 6(IL 6)的影响 ,将不同质量浓度的HlpA和 (或 )LTA放入培养的细胞中 ,作用不同时间后收集上清液 ,用IL 6依赖株 7TD1细胞测定样品IL 6活性。结果显示 ,链球菌HlpA( 0～ 1 0 0mg/L)在体外以剂量和时间依赖方式促进MΦ产生IL 6。LTA和HlpA的混合物对IL 6的产生呈协同增强作用 ;肝素则起抑制作用
|
| 关 键 词： | 链球菌 巨噬细胞 白细胞介素6 |
| 收稿时间： | 2002-07-14 |
| 修稿时间： | 2002年7月14日 |
Streptococcal Histone-Like Protein Induces Murine Peritoneal MΦ to Produce IL-6 |
| |
| Shen Haizhong,Zhang Liping,Ping Guoling,Zhang Hongchun,Jing Xuefang,Li Yuying,Li Yulan.Streptococcal Histone-Like Protein Induces Murine Peritoneal MΦ to Produce IL-6[J].Journal of Capital University of Medical Sciences,2003,24(1):11-13. |
| |
| Authors: | Shen Haizhong Zhang Liping Ping Guoling Zhang Hongchun Jing Xuefang Li Yuying Li Yulan |
| |
| Institution: | Shen Haizhong,Zhang Liping,Ping Guoling,Zhang Hongchun,Jing Xuefang,Li Yuying,Li Yulan Department of Immunology,Capital University of Medical Sciences Li Weihong,Zhang Haiyan Department of Cell Biology,Capital University of Medical Sciences |
| |
| Abstract: | To evaluate the effect of Streptococcus HlpA on interlukin-6(IL-6)production by murine peritoneal MΦ, HlpA and/or LTA were added to the cultured MΦ and maintained for different time periods. IL-6 activity was measured by means of 7TD1 cells. The results showed that the IL-6 production from MΦ induced by HlpA of Streptococcus was time and concentration dependent in vitro. There was a synergisticly increased response on the production of IL-6 induced by the mixture of HlpA and LTA, as compared to HlpA alone. On the contrary, the addition of heparin could deduce the IL-6 production. |
| |
| Keywords: | Streptococcus macrophage interlukin 6 |
| 本文献已被 CNKI 维普 等数据库收录！ |
| 点击此处可从《首都医学院学报》浏览原始摘要信息 |
| 点击此处可从《首都医学院学报》下载免费的PDF全文 |
|
