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Hypothetical membrane mechanisms in essential tremor |
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| Authors: | Aasef G Shaikh Kenichiro Miura Lance M Optican Stefano Ramat Robert M Tripp David S Zee |
| Affiliation: | (1) Department of Neurology, The Johns Hopkins University, Baltimore, MD, USA;(2) National Eye Institute, National Institutes of Health, Baltimore, MD, USA;(3) University of Pavia, Pavia, Italy;(4) FlexAble Systems, Fountain Hills, AZ, USA;(5) Graduate School of Medicine, Kyoto University, Kyoto, Japan |
| Abstract: | BackgroundEssential tremor (ET) is the most common movement disorder and its pathophysiology is unknown. We hypothesize that increased membrane excitability in motor circuits has a key role in the pathogenesis of ET. Specifically, we propose that neural circuits controlling ballistic movements are inherently unstable due to their underlying reciprocal innervation. Such instability is enhanced by increased neural membrane excitability and the circuit begins to oscillate. These oscillations manifest as tremor. |
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