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Metastasis suppressors and the tumor microenvironment |
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| Authors: | Cook Leah M Hurst Douglas R Welch Danny R |
| Affiliation: | a Department of Pathology, The University of Alabama at Birmingham, Birmingham, AL, USA;b Department of Cell Biology, The University of Alabama at Birmingham, Birmingham, AL, USA;c Department of Pharmacology and Toxicology, The University of Alabama at Birmingham, Birmingham, AL, USA;d Department of Comprehensive Cancer Center, The University of Alabama at Birmingham, Birmingham, AL, USA;e National Foundation for Cancer Research – Center for Metastasis Research, The University of Alabama at Birmingham, Birmingham, AL, USA |
| Abstract: | The most lethal and debilitating attribute of cancer cells is their ability to metastasize. Throughout the process of metastasis, tumor cells interact with other tumor cells, host cells and a variety of molecules. Tumor cells are also faced with a number of insults, such as hemodynamic sheer pressure and immune selection. This brief review explores how metastasis suppressor proteins regulate interactions between tumor cells and the microenvironments in which tumor cells find themselves. |
| Keywords: | Nm23 RECK BRMS1 KISS1 Kisspeptin TIMP LSD1 CD44 OGR1 E-cadherin JNKK1/MKK7/p38 RhoGDI2 DLC1 DRG1 Gelsolin KAI1 SseCKS/Gravin/AKAP12 HUNK Caspase 8 Ribonucleotide reductase M1 Angiogenesis Review |
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