乳腺钙化活检标本的病理取材的块状定位法

目的：介绍一种新颖的切割线标记及／或金属标记的乳腺钙化活检标本的块状定位法，以增加病理医生在切片取材时的精确程度。方法：回顾分析钙化病灶BI—RADS分级达IV级以上5例患者6侧乳房的活检方法和标本块状定位法。首先对于钙化灶进行开放式手术活检。钙化灶的上下、内外及深浅三维定位参照内外侧斜位和头足位钼靶片所示的钙化位置及标尺刻度；切下标本之后，进行块状定位：将标本平行地或放射状地两次到三次切割和／或配合金属标记将标本分割成块；接着标本摄x片，确定钙化灶被完整切除；最后会同病理科医生将块状定位下的可疑组织进行准确的取材和病理检查，从而完成诊断。结果：标本x片显示钙化灶均被完整切取；通过切割线和金属标记的方式完成了标本x片中的块状定位及对应的标本大体观中的块状定位；病理科医生可以准确地根据标本x片所示的可疑位置在标本中精确取材到对应组织。结论：乳腺钙化活检标本的块状定位可以增加标本切片取材时的精确程度。

A massive localization method for specimen of breast calcification in open excisional biopsy

Objective：A new massive localization method with cutting line and/or metal marker is introduced to increase the precise level when the suspicious calcification tissue sample is drawn from the specimen by pathologists. Methods：Open excisional biopsy and massive localization method （5 pts,6 breasts with cluster micro - calcification scored more than grade IV by BI - RADS） were retrospectively analysized. Routinely, an open excisional biopsy to calcification locus was conducted first after the operators observed three - dimensional positioning of calcification by referring to MLO and CC mammography as well as indicated scaleplate. Then the specimen obtained from the open cx- cisional - biopsy was subjected to massive localization by cutting and/or metal marker, next the mammography of the massive localization specimen was observed to decide whether calcification locus was completely cut. Last the suspi- cious tissue was precisely drawn from the specimen and made into frozen slices by a consult between the operator and the pathologists. Results： The specimen mammographies showed six calcification locuses were completely removed （ 100% ）. Various locations in both the specimen and specimen mammography were marked clearly by twice or thrice cutting and/or metal marker（ 100% ） ,the pathologists could precisely draw the suspicious tissue from the specimen by the guide of cutting marker and/or metal marker in the specimen and a comparable observation to specimen mammog- raphy. Conclusion：This new massive localization method with cutting line and/or metal marker can effectively in- crease the precise level when a suspicious calcification locus is drawn from a specimen by pathologists.