惊恐障碍患者血清脂质水平的初步研究

探讨惊恐障碍患者的血脂水平及明确高胆固醇 (Tch)水平是否仅伴发于惊恐障碍或与其他精神障碍有关。　　方法　采用酶法测定在性别、年龄上相匹配的 3 0例惊恐障碍患者、3 0例抑郁症患者及 3 0例正常对照者的血清脂质水平。　　结果　惊恐障碍男患者的血清Tch水平明显高于抑郁症患者和正常对照者 ,稳定内科疾病与高血清Tch水平无关 ;在抑郁症组中 ,焦虑障碍史者的血清Tch水平显著增高。　　结论　提示惊恐障碍男患者的血清高Tch水平 ,可能涉及去甲肾上腺素或 5-羟色胺活性增高假说机制

A preliminary study of serum lipid levels in patients with panic disorder.

Objective To study serum lipid levels in patients with panic disorder and clarify whether the higher cholesterol levels found in patients with panic disorder are a complication of panic disorder only or are associated with any psychiatric disorder. Method Serum lipid levels were meadured by means of enzymatic assay in 30 patients with panic disorder, 30 patients with major depression,and 30 normal control subjects.The three groups were matched for sex and age. Results The male patients with panic disorder had significantly higher serum cholesterol(Tch) levels than the male patients with major depression and the normal control subjects had. The presence of stable medical conditions was not associated with higher Tch levels. Among the patients with major depression,histories of anxiety disorders were associated with significant elevation of serum Tch level. Conclusions It suggested that higher Tch levels in male patients with panic disorder were hypothesized to be a result of increased nordrenergic or serotonin activity.