Geometric information is required for allothetic navigation in mice |
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| Authors: | Fellini Laetitia Morellini Fabio |
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| Institution: | 1. Zentrum für Molekulare Neurobiologie Hamburg, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany;2. Experimentelle Neuropädiatrie, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany;1. The Pennsylvania State University College of Medicine, Department of Neural and Behavioral Sciences, Hershey, PA 17033, USA;2. The Pennsylvania State University College of Medicine, Department of Surgery, Hershey, PA 17033, USA;1. Department of Psychology, University of Calgary, Calgary, Alberta, Canada;2. Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada;3. Department of Cell Biology and Anatomy, University of Calgary, Calgary, Alberta, Canada;1. Department of Pharmacology and Toxicology, School of Medical Sciences, University of Otago Medical School, New Zealand;2. Brain Health Research Centre, University of Otago, Dunedin, New Zealand;3. Institute of Fundamental Sciences, Massey University, Palmerston North, New Zealand;1. Department of Otolaryngology, Wake Forest School of Medicine, WFUBMC-OHNS, Medical Center Boulevard, Winston-Salem, NC 27157, United States;2. Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, United States;3. Department of Radiology, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, United States;4. Mountain Empire Radiology, 1301 Sunset Drive Suite 3, Johnson City, TN 37604, United States;1. Mouse Neurobehavioral Phenotyping Facility, Center for Biometric Analysis, The Jackson Laboratory, Bar Harbor, ME 04609, United States;2. Psychology Department, Northern Illinois University, DeKalb, IL 60115, United States;3. Psychological and Brain Sciences, Dartmouth College, Hanover, NH 03755, United States;1. Center for Logic, Language, and Cognition, University of Torino, Italy;2. Computer Science Department, University of Torino, Italy |
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| Abstract: | In tasks for allothetic navigation, animals should orientate by means of distal cues. We have previously shown that mice use several forms of information to navigate, among which geometry, i.e. the shape of the environment, seems to play an important role. Here we investigated whether geometric features of the environment are necessary for allothetic navigation in mice. Mice were trained to navigate in a circular water maze by means of four distal landmarks distributed either symmetrically (symmetry group) or asymmetrically (asymmetry group) around the maze. Thus, mice could locate a hidden platform by either differentiating the landmarks based on their intrinsic features (symmetry group) or in addition by geometric information, i.e. based on the relative distances between landmarks (asymmetry group). Data indicated that place learning occurred only in the asymmetry group. The results support the idea that mice navigate by using the relational properties between distal landmarks and that geometric information is required for proper allothetic navigation in this species. |
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