| 冠心病病人血清sCD14和hs-CRP变化及其临床意义 |
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| 引用本文： | 朱京伟,刘成玉.冠心病病人血清sCD14和hs-CRP变化及其临床意义[J].青岛大学医学院学报,2008,44(2):156-158. |
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| 作者姓名： | 朱京伟 刘成玉 |
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| 作者单位： | 青岛大学医学院诊断学教研室,山东,青岛,266021 |
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| 摘 要： | 目的 探讨冠心病(CHD)病人血清可溶性CD14(sCD14)和超敏C反应蛋白(hs-CRP)的变化及其临床意义.方法 选取120例CHD病人(CHD组),其中急性心肌梗死(AMI)、不稳定型心绞痛(UAP)和稳定型心绞痛(SAP)病人各40例,应用ELISA法测定血清sCD14浓度,应用散射比浊法测定血清hs-CRP浓度,并与40例健康体检者(对照组)进行比较.结果 CHD组sCD14浓度显著高于对照组(t′=15.75,P<0.01);AMI、UAP、SAP病人sCD14浓度与对照组比较,差异有显著性(F=132.94,q=9.70～27.58,P<0.01);AMI、UAP、SAP病人sCD14浓度差异有显著性(q=5.86～17.88,P<0.01),且以AMI病人增高最明显.CHD组hs-CRP浓度显著高于对照组(t′=10.68,P<0.01);AMI、UAP病人hs-CRP浓度明显高于SAP病人和对照组(F=80.25,q=5.91～20.11,P<0.01),且以AMI病人增高最明显.结论 血清sCD14和hs-CRP浓度升高与冠状动脉病变程度密切相关,对冠状动脉病变程度有预测价值.
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| 关 键 词： | 冠状动脉疾病 抗原 CD14 C反应蛋白质 |
| 文章编号： | 1672-4488(2008)02-0156-03 |
| 修稿时间： | 2007年8月1日 |
THE CHANGES AND THEIR CLINICAL SIGNIFICANCE OF SOLUBLE CD14 AND HYPERSENSITIVE C-REACTIVE PROTEIN IN PATIENTS WITH CORONARY HEART DISEASE |
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| ZHU JING-WEI,LIU CHENG-YU.THE CHANGES AND THEIR CLINICAL SIGNIFICANCE OF SOLUBLE CD14 AND HYPERSENSITIVE C-REACTIVE PROTEIN IN PATIENTS WITH CORONARY HEART DISEASE[J].Acta Academiae Medicinae Qingdao Universitatis,2008,44(2):156-158. |
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| Authors: | ZHU JING-WEI LIU CHENG-YU |
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| Institution: | ZHU JING-WEI,LIU CHENG-YU(Department of Diagnostics,Qingdao University Medical College,Qingdao 266021,China) |
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| Abstract: | Objective To explore the changes and clinical significance of serum soluble CD14(sCD14) and hypersensitive C-reactive protein(hs-CRP) levels in patients with coronary heart disease(CHD). Methods This study consisted of 120 patients with CHD who were evenly divided into three groups: acute myocardial infarction(AMI),stable angina pectoris(SAP),and unstable angina pectoris(UAP),and 40 healthy subjects servers as controls.The serum sCD14 was determined by enzyme-linked immunosorbent assay(ELISA),and serum hs-C... |
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| Keywords: | Coronary artery disease Antigens CD14 C-reactive protein |
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