Frequency and distribution of binucleate cells in oral epithelium of several species of laboratory rodents |
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| Authors: | J Ibrahim S J Gerson J Meyer |
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| Institution: | 1. University of British Columbia, Department of Psychology, 2136 West Mall, Vancouver BC V6T 1Z4, Canada;2. BC Children’s Hospital MRI Research Facility, 4480 Oak Street, Vancouver, BC V6H 0B3, Canada;3. University of British Columbia, Djavad Mowafaghian Centre for Brain Health, 2215 Wesbrook Mall, Vancouver, BC V6T 1Z3, Canada;1. Institute of Neuroscience and Physiology, Section of Psychiatry and Neurochemistry, University of Gothenburg, Sweden;2. Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan;3. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden;4. Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden;1. Vall d''Hebron University Hospital and Vall d''hebron Institute of Oncology (VHIO), Barcelona, Spain;2. Basser Center for BRCA and Abramson Cancer Center, University of Pennsylvania, Philadelphia, USA;3. Perelman School of Medicine at the University of Pennsylvania, Philadelphia, USA;4. Universitat Politècnica de Catalunya, Barcelona, Spain;5. Catalan Institute of Oncology, IDIBELL, Barcelona, Spain;6. Catalan Institute of Oncology, IDIBGI, Girona, Spain;7. Hospital Sant Pau, Barcelona, Spain;8. Hospital Universitari, Parc Taulí Sabadell, Consorci Sanitari de Terrassa, Barcelona, Spain;9. University of Lleida-Lleida Biomedical Research Institute (UdL-IRBLleida), Lleida, Spain;10. Sunnybrook Health Sciences Centre, Toronto, Canada;11. Anderson Cancer Centre, Houston, TX, USA;1. Department of Biochemistry, School of Life Sciences, University of KwaZulu-Natal, (Westville Campus), Durban, 4000, South Africa;2. Nutrition and Toxicology Division, Federal Institute of Industrial Research, Lagos, Nigeria;3. Department of Health Sciences, Faculty of Health and Environmental Sciences, Central University of Technology, Bloemfontein, 9301, South Africa |
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| Abstract: | Keratinocytes in certain regions of rodent oral epithelium have a tendency to form a peculiar type of binucleate cell. The nuclei, in contrast to those in binucleate cells in most other tissues, are closely apposed with a flat interface, tetraploid and of approx. equal size. Binucleate cells were absent from the oral epithelium of several unrelated non-rodent mammalian species, but they occurred in descending order of frequency in guinea pig, rat, hamster and mouse; they were in epithelia of the lining mucosa, but absent from epithelia of the masticatory mucosa. In buccal epithelium of the rat, they constituted 2.5 per cent of the basal cells and 8.2 per cent of the lower spinous cells. This frequency was maintained in the succeeding cell layers. Regions of stimulated epithelium in zinc-deficient rats showed a four-fold increase over controls in frequency in the germinative cell layers and persistently higher frequency in succeeding layers, including in parakeratin. The mode of formation of the cells is unknown, but it was not associated with a lag in cytoplasmic division. |
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