盐酸戊乙奎醚治疗急性有机磷农药中毒的观察

目的观察新型抗胆碱药盐酸戊乙奎醚治疗急性有机磷农药中毒的疗效。方法本组120例急性有机磷农药中毒患者,随机分为盐酸戊乙奎醚治疗组与阿托品对照组。采用推荐剂量按轻、中、重分组治疗,并对治疗效果进行比较。结果盐酸戊乙奎醚对不同程度急性有机磷农药中毒患者毒蕈碱样症状的控制疗效确实可靠,与对照组相比,达到阿托品化时间无明显差异(P>0.05),但血清心肌酶释放峰值、住院时间、住院费用及用药过量发生率均显著降低(P<0.05),特别是给药次数极显著减少(P<0.001)。对急性有机磷农药中毒患者昏迷时间及因胆碱能危象所致呼吸衰竭,呼吸恢复时间均明显缩短(P<0.05)。结论盐酸戊乙奎醚在治疗急性有机磷农药中毒多方面明显优于阿托品,可以取代传统抗胆碱药阿托品治疗急性有机磷农药中毒。

Clinical Observation of Penehyclidine in the Treatment of Organic Pesticides Poisoning

Objective Observation new antiemetic penehyclidine ether(PCHE) in the treatment of acute organophosphate pesticide poisoning effects. Methods 120 cases were randomly assigned to treatment with atro cases of acute organophosphorus pesticide poisoning(AOPP)pine PCHE control group, use the recommended dosage by light, a retreatment, and treatment were compared. Results PCHE of muscarinic-like symptoms in patients with varying degrees of AOPP authoritative control efficacy, compared with the control group. Atropinization time no significant difference(P>0.05), but the release of serum monoflaoro buzzer value hospitalization. Drug overdoses and hospitalization rates weresignificantly lower (P<0.05).It is a very significant reduction in the number of special administration (P<0.001). AOPP patients on cholinergic crisis-induced coma and respiratory failure due to respiratory recovery time was significantly shorter (P<0.05) Conclusion PCHE than atropine in the treatment of various AOPP. Atropine can replace conventional antiemetic treatment AOPP.