| 卡托普利对冠心病患者血清一氧化氮及脂质过氧化物水平的影响 |
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| 引用本文： | 刘同涛,姚洁芬,周瑞海,高海青,张爱馨,王树春. 卡托普利对冠心病患者血清一氧化氮及脂质过氧化物水平的影响[J]. 山东大学学报(医学版), 1995, 0(4) |
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| 作者姓名： | 刘同涛 姚洁芬 周瑞海 高海青 张爱馨 王树春 |
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| 作者单位： | 莱芜市第二人民医院 |
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| 摘 要： | 测定了８０例冠心病（ＣＨＤ）患者血清一氧化氮（ＮＯ）、脂质过氧化终产物丙二醛（ＭＤＡ）的水平，并观察了卡托普利对ＣＨＤ患者血清ＭＤＡ及一氧化氮水平的影响。结果表明，１．ＣＨＤ患者血清ＮＯ水平显著低于对照组，而血清ＭＤＡ水平显著高于对照组（Ｐ均＜０．０１）；２．ＣＨＤ患者血清ＭＤＡ水平与ＮＯ水平呈显著负相关（ｒ＝－０．５８，Ｐ＜０．０１）；３．卡托普利可抑制ＣＨＤ患者脂质过氧化反应，降低血清ＭＤＡ水平，升高血清ＮＯ水平。提示ＣＨＤ患者脂质速或化反应增强，内皮功能失调，而卡托普利：可以升高ＮＯ水平，对ＣＨＤ的防治具有重要意义。
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| 关 键 词： | 冠状动脉疾病；一氧化氮；过氧化脂质类；卡托普利 |
EFFECT OF CAPTOPRIL ON THE LEVEL OF LIPID PEROXIDATION AND NITRIC OXIDE IN PATIENTS WITH CORONARY HEART DISEASE |
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| Liu Tongtao, Yao Jiefen, Zhou Ruihai,et al. EFFECT OF CAPTOPRIL ON THE LEVEL OF LIPID PEROXIDATION AND NITRIC OXIDE IN PATIENTS WITH CORONARY HEART DISEASE[J]. Journal of Shandong University:Health Sciences, 1995, 0(4) |
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| Authors: | Liu Tongtao Yao Jiefen Zhou Ruihai et al |
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| Abstract: | Serum nitric oxide (NO) and malondialdehyde ( MDA )were measured in patients with coronary heart disease(CHD), and the effects of captopril on the level of NO and MDA were investigated. The results showed that 1.NO level was significantly lower and MDA higher in patients with CHD than in normal subjects. 2.Captopril significantly decreased MDA and increased NO level in patients with CHD. These indicate that CHD patients are with higher lipid peroxidation and lower NO level and captopril could inhibit lipid peroxidation and increase NO, thus could be beneficial to the prevention and treatment of CHD. |
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| Keywords: | Coronary disease Nitric oxide Lipid peroxides Captopril |
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