Synthesis of 6,7-dialkoxy-2-arylmethylidene-2,3- dihydrobenzo[4,5]imidazo[2,1-b][1,3]thiazol-3-ones exhibiting anti-inflammatory activity |
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Authors: | Labanauskas L Brukstus A Udrenaite E Gaidelis P Bucinskaite V Dauksas V |
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Institution: | Faculty of Chemistry, Vilnius University, Lithuania. linas.labanauskas@chf.vu.lt |
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Abstract: | New 6,7-dialkoxy-2-arylmethylidene-2,3- dihydrobenzo4,5]imidazo2,1-b]1,3]thiazol-3-ones (3a-h, 4b, c, e, g) were synthesized from 2-(5,6-dialkoxy-1H-benzod]imidazol-2-ylsulfanyl)acetic acids (1, 2) and corresponding aromatic aldehydes in acetic anhydride. The compounds 3e, f and 4b, g were also synthesized from corresponding aromatic aldehydes and 6,7-dialkoxy-2,3-dihydrobenzo4,5]imidazo2,1-b]1,3]thiazol -3-ones (5, 6) obtained by the cyclization of the acids 1 and 2 in acetic anhydride. The synthesized compounds 3a-h and 4b, c, e, g exhibit anti-inflammatory activity. |
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