探讨水蛭微粉对急性脑梗塞患者的临床治疗作用及机理

目的：探讨水蛭微粉对急性脑梗塞患者的临床治疗作用及机理。方法：63例脑梗塞患者（病程在3?d以内）随机分为3组。A组（对照组）：21例，常规西药治疗；B组（粗粉组）：21例，常规西药加水蛭粗粉治疗；C组（微粉组）：21例，常规西药加水蛭微粉治疗。观察脑梗塞患者的临床治疗效果，治疗前后的血液血管性假血友病因子（vWF），血小板α 颗粒膜蛋白140（GMP 140、CD62p）水平。结果：两种水蛭制剂均能提高脑梗塞患者临床疗效，以微粉组疗效明显，总有效率比较：B组优于A组，P<0.05；C组优于A组，P<0.01。愈显率比较：C组优于B组，P<0.05。3组患者上述两项实验指标治疗后也均有改善，两水蛭组优于对照组，P＜0.01，C组优于B组，P＜0.01。结论：水蛭微粉较水蛭粗粉更能有效地提高脑梗塞患者的临床疗效，更能有效地抑制血管内皮损伤、血小板活化。

Effect of vWF, GMP-140 of ultra-fine particle of leeches in treating acute brain infarction disease

Objective: To estimate the value of ultra-fine particle of Leeches on acute brain infarction disease.Methods: A total of 63 cases of early brain infarction disease were divided into 3 groups: group A,treated with normal medicine;group B,treated with normal medicine and bigger particle of Leeches;group C,treated with normal medicine and ultra-fine particle of Leeches.The clinical symptom before and after treatment was observed,and also the level of blood Von Wille brand factor(vWF),p-selection(GMP-140) were observed.Results: The total response rate of group C and B was higher than that of group A(P<0.01, 0.05).The curative and marked response rates of group C were higher than those of group B(P<0.05).The improvement of blood vWF,GMP-140 of group C was better than that of group B(P<0.05,0.01);and that of group B was better than group A(P<0.05,0.01).Conclusion: There are serious vascular endothelium injury,platelet activity in both brain infarction patients.Ultra-fine particle of Leeches is more effective in treating brain infarction disease than bigger particle of Leeches,and it is more effective in improving the blood levels of vWF,GMP-140.