心律平和乙吗噻嗪治疗频发性室性早搏的临床观察

目的 观察心律平与乙吗噻嗪的临床疗效,有效剂量及副作用。方法 选择了47例口服心律平(Pr)和乙吗噻嗪(Et)的频发性室性早搏病人,进行两药的治疗效果、有效治疗剂量和副作用的比较分析。结果 Pr和Et治疗频发性室性早搏的总有效率分别为87.1％和74.1%。Pr治疗频发性室性早搏的平均有效治疗剂量为502±227.6mg/日,明显低于Et(667±240.1mg/日),P值小于0.05。当每日用药剂量为450mg和600mg时,Pr组的有效率分别为54.8％和66.7％,Et组的有效率分别为22.2％和37.0％。两组比较无显著性差异。Pr和Et的副作用发生率分别为16.1％和29.6％。结论Pr和Et治疗频发性室性早搏均有较好效果。并且显示其效果与用药剂量有关。其中Pr的有效治疗剂量较小且耐受性好,可作为治疗频发性室性早搏的首选药物。

Evaluation of effects of propafenone and ethmozine in treating patients with frequent premature ventricular contraction

Objective To investigate the clinical efficacy, dose and side effect of oral propafenone and ethmozine. Methods 47 patients with freguent Premature Vautricular Contraction (PVC) who had taken orally propafenone and ethmozine were studied and comparatively analyzed. Results The total effective rate of propafenone and ethmozine in treating patients with frequent PVC were 87. 1% (27 of 31 cases) and 74. 1% (20 of 27 cases) separately. The mean daily effective dose of propafenone (502 227.6mg daily) was significantly lower than that of ethmozine(667 240. Img daily) in treating patients with frequent PVC (P<0. 05). With the doses of 450mg and 600mg daily, seventeen of 31 cases (54. 8%)and twenty -two of 31 cases (67. 7%) were separately effective in propafenone therapy group, and six of 27 cases (22. 2%) and ten of 27 caes (37. 0%) were separately effective in ethmozine therapy group. Adversity occurred in five of 31 cases (16-1%) during propafenone therapy and in eight of 27 cases (29. 6%) during ethmozine therapy. Conclusion Propafeone and ethmozine are very effective for treatment of frequent PVC.